Tujuan penelitian ini untuk mengetahui pengaruh penerapan strategi pembelajaran aktif Question Student Have (QSH) terhadap hasil belajar Biologi ranah pengetahuan, sikap dan keterampilan siswa. Penelitian ini dilakukan mulai bulan Nopember 2014 di SMA Negeri 1 Tarakan. Penelitian ini adalah penelitian eksperimen semu dengan populasi siswa kelas X dan sampel sebanyak 2 kelas. Teknik pengambilan sampel menggunakan Cluster Purposive Sampling. Data di analisis menggunakan software SPSS 22.0 for Window. Teknik analisis data menggunakan uji Manova. Hasil penelitian menunjukkan bahwa terdapat pengaruh penerapan strategi pembelajaran aktif Question Student Have (QSH) terhadap hasil belajar Biologi siswa ranah pengetahuan berdasarkan Tes Pilihan ganda (Pretes dan Postes) nilai harga F sebesar 18.974 dengan nilai signifikansi hasil belajar biologi siswa sebesar 0,000 (< 0,05) dan pengaruh penerapan strategi pembelajaran aktif Question Student Have (QSH) terhadap hasil belajar Biologi siswa ranah sikap berdasarkan lembar observasi siswa, maka nilai harga F sebesar 9.460 dengan nilai signifikansi ranah sikap siswa sebesar 0,003 (< 0,05), sedangkan ranah keterampilan berdasarkan lembar observasi siswa nilai harga F sebesar 15.474 dengan nilai signifikansi ranah keterampilan siswa sebesar 0,000 (< 0,05). Dengan demikian dapat disimpulkan bahwa terdapat pengaruh penerapan strategi pembelajaran aktif Question Student Have (QSH) terhadap hasil belajar Biologi siswa kelas X SMA Negeri 1 Tarakan.

The purpose of this research was to find out the influence of the implementation of the active learning Question Student Have (QSH) strategy towards the biology learning result in knowledge domain, attitude and students’skill. This research was conducted starting from November 2014 in SMA Negeri 1 Tarakan. This research was an quasi experimental research with population of the students class X and the sample of two classes. The technique of data collection was using Cluster Purposive Sampling. The data were analyzed by using software SPSS 22.0. The technique to analyze the data was using Manova testing. The result of the research showed that there was an influence of the implementation of the active learning Question Student Have (QSH) strategy towards the students’ Biology learning result in knowledge domain based on the multiple choice test (Pretest dan Postest) the price score F was 18.974 with the significant of the students’ biology learning result 0,000 (< 0,05) and the influence of the implementation of the active learning Student Have (QSH) strategy towards the students’ biology learning result in attitude domain based on the students’observation sheet, the price score F was 9.460 with the significant of the students’attitude domain 0,003 (< 0,05), while the skill domain based on the students’observation sheet with the price score F was 15.474 with the significant of the students’ skill domain score sebesar 0,000 (< 0,05). Therefore, it can be concluded that there was an influence of the implementation of the active learning Question Student Have (QSH) strategy towards the Biology learning result of the students class in SMA Negeri 1 Tarakan.