Penelitian bertujuan untuk menghasilkan produk komik edukasi biologi pada materi sistem pertahanan tubuh manusia yang sesuai dengan karakteristik anak SMA dan Menghasilkan produk komik edukasi biologi pada materi sistem pertahanan tubuh manusia yang tervalidasi layak dan layak pakai. Penelitian ini dibatasi sampai pada tahap ke tujuh model Borg & Gall (1983), menggunakan 3 orang validator ahli, yaitu; ahli materi, ahli media dan ahli praktisi guru biologi. uji coba lapangan dilakukan disekolah MAN Tarakan, uji coba lapangan awal menggunakan siswa kelas XII IPA sebanyak 8 orang dan uji coba lapangan utama menggunakan siswa kelas XI IPA sebanyak 37 orang. Komik edukasi hasil pengembangan memiliki karakteristik sebagai berikut: komik berukuran A5, komik berjudul War In My Body, tokoh dalam komik adalah dua orang anak SMA dan tiga sel darah putih,semi warna, menggunakan SK 3 dan KD 3.8, terdiri dari tiga bagian, yaitu; sistem pertahan tubuh manusia, gangguan sistem kekebalan tubuh dan catatan Alisa (rangkuman dan glosarium). Hasil validasi ahli materi sebesar 77,5 % dengan kategori layak, ahli media sebesar 78,3 % dengan kategori layak, validasi praktisi guru biologi sebesar 90 % dengan kategori sangat layak, hasil angket respon siswa uji coba lapangan awal sebesar 77,19 % dengan kategori setuju, angket respon siswa uji coba lapangan utama sebesar 79,32 % dengan kategori setuju, observasi keterpakaian komik sebesar 86,67 % dengan kategori sangat tinggi, dan gain score pretest-postest sebesar 61 % kategori sedang. Sehingga disimpulkan komik edukasi yang dikembangkan tervalidasi layak dan layak pakai.

This research has purpose to make a biology educational comic media with human body protection system as the material which was appropriate to the characteristics of senior high school students as well as valid and feasible. This research was limited only to the seventh stage of Borg & Gall (1983) model, validated by 3 experts, i.e; material expert, layout and design expert, and biology practitioner expert. Try out was conducted at MAN Tarakan, initial field try out tested 8 students of eleventh grade of science major and the main field try out tested 37 students of eleventh grade of science major. Biology educational comic as the result of development has the following characteristics: the size of comic is A5, entitled War in My Body, the main character of the comic are two senior high school students and three white blood cells, semi-colored, contained 3 Standard Competence and Basic Competence 3.8, consists of three parts, namely; human body protection system, disorder of body defense system, and Alisa's note (summary and glossary).The result of validation from material expert was 77,5% with viable category, 78,3% with viable category from layout and design expert, and 90% with highly-viable category from biology practitioner expert, the result of evaluation questioner for students in initial field try out was 77,81% with Agree category, the result of evaluation questioner for students in main field try out was 79,12% with Agree category, comic usage observation was 86,67% with Very High category, and gain score pretest-postest was 61% with medium category. Therefore, it can be concluded that the Biology Educational Comic which has developed is validated as viable and feasible.